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Arginine metabolism in uricotelic species - doi: 10.4025/actascianimsci.v32i4.10990 Animal Sciences
Fernandes, Jovanir Inês Müller; Universidade Federal do Paraná; Murakami, Alice Eiko; UEM.
Due to the lack of a complete urea cycle, uricotelic species, such as broilers, are not able to synthesize de novo arginine (Arg), thus depending exclusively on dietary Arg. High levels of dietary lysine (Lys) increase the demand for Arg because of the antagonistic relationship between these amino acids. The Arg-Lys antagonism promotes an expressive increase in the renal Arg activity and consequently induces the degradation of Arg and the decrease in the activity of glycine amidinotransferase, an enzyme that uses Arg in the synthesis of muscle creatin. Arg is considered an important modulator of immunological and physiological processes. The degradation of Arg produces ornithine, a precursor of polyamines that are key to cell division, DNA synthesis, and...
Palavras-chave: Carbamoyl phosphatase synthetase; Creatine; Immune system; Nitric oxide; Polyamines; Urea cycle carbamoyl phosphatase synthetase; Creatine; Immune system; Nitric oxide; Polyamines; Urea cycle.
Ano: 2010 URL: http://periodicos.uem.br/ojs/index.php/ActaSciAnimSci/article/view/10990
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L-arginine metabolism in mitochondria isolated from the liver of Antarctic fish Notothenia rossii and Notothenia neglecta BABT
Rodrigues,Edson; Ribeiro,Ana Cristina Miguez Teixeira; Bacila,Metry.
The arginase tissue distribution, the biochemical properties of the argininolytic system and the subcellular localization of the enzymes carbamoylphosphate synthetase, ornithinecarbamoyl transferase, glutamine synthetase and arginase in Antarctic fish, N. neglecta and N. rossii were the main aims of the present work. The tissue with highest argininolytic activity was the kidney distal portion amounting as much as four times the specific activity of the hepatic tissue. Arginase and ornithine carbamoyltransferase were found as mitochondrial enzymes, while glutamine synthetase and carbamoylphosphate synthetase were found as cytosolic enzymes. Argininolytic assays with isolated mitochondria gave values of Kmapp for the hydrolysis of arginine 2 to 3.5 times...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antarctic fish; Arginine; Arginase; Urea cycle; N. neglecta; N. rossii.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000600017
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